PittsburghV1, Main, Exploration, bibRecord, 004D79

Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites

Identifieur interne : 004D79 ( Main/Exploration ); précédent : 004D78; suivant : 004D80

Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites

Auteurs : Irina Stepanov [États-Unis] ; Erin Sebero [États-Unis] ; RENWEI WANG [États-Unis] ; Yu-Tang Gao [République populaire de Chine] ; Stephen S. Hecht [États-Unis] ; Jian-Min Yuan [États-Unis]

Source :

International journal of cancer : (Print) [ 0020-7136 ] ; 2014.

RBID : Pascal:14-0092618

Descripteurs français

Pascal (Inist)
- Tabagisme, Tabac, Nitrosamine, Tumeur maligne, Exposition, Cancer du poumon, Facteur risque, Risque, Etude cohorte, Cohérence, Animal, Rat, Marqueur biologique, Cancérologie.
Wicri :
- topic : Tabagisme, Tabac.

English descriptors

KwdEn :
- Animal, Biological marker, Cancerology, Coherence, Cohort study, Exposure, Lung cancer, Malignant tumor, Nitrosamine, Rat, Risk, Risk factor, Tobacco, Tobacco smoking.

Abstract

The tobacco-specific nitrosamines N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are potent carcinogens for the rat esophagus and lung, respectively. Consistent with the animal carcinogenicity data, we previously reported a remarkably strong association between prospectively measured urinary total NNN, a biomarker of human NNN intake, and the risk of developing esophageal cancer among smokers in the Shanghai Cohort Study. We also demonstrated that urinary total 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanol (NNAL), a biomarker of exposure to the lung carcinogen NNK, is strongly associated with the risk of lung, but not esophageal cancer in smokers. In this study, we investigated the potential relationship between NNN intake and lung cancer risk in the same cohort. The prospectively collected urine samples from lung cancer cases and matcing controls selected for this study, an current smokers, have been previously analyzed for total NNAL, cotinine (a biomarker of nicotine intake) and phenanthrene tetraol (Phel) la biomarker of exposute to polycyclic aromatic hydrocarbons). Urinary levels of total NNN were not associated with the risk of lung cancer odds ratios (95% confidence intervals) associated with the second and third tertiles of total NNN, relative to the lowest tertile, were 0.82 (0.36-1.88) and 1.02 (0.39-2.89), respectively (p for trend = 0.959), after adjustment for self-reported smoking history, urinary cotinine and PheT. The results of this study reaffirm the previously reported specificity of urinary total NNN and total NNAL as predictors of esophageal and lung cancer risks, respectively, in smokers, and demonstrate remarkable coherence between rat target tissues of these carcinogens and susceptibility to cancer in smokers.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The tobacco-specific nitrosamines N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are potent carcinogens for the rat esophagus and lung, respectively. Consistent with the animal carcinogenicity data, we previously reported a remarkably strong association between prospectively measured urinary total NNN, a biomarker of human NNN intake, and the risk of developing esophageal cancer among smokers in the Shanghai Cohort Study. We also demonstrated that urinary total 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanol (NNAL), a biomarker of exposure to the lung carcinogen NNK, is strongly associated with the risk of lung, but not esophageal cancer in smokers. In this study, we investigated the potential relationship between NNN intake and lung cancer risk in the same cohort. The prospectively collected urine samples from lung cancer cases and matcing controls selected for this study, an current smokers, have been previously analyzed for total NNAL, cotinine (a biomarker of nicotine intake) and phenanthrene tetraol (Phel) la biomarker of exposute to polycyclic aromatic hydrocarbons). Urinary levels of total NNN were not associated with the risk of lung cancer odds ratios (95% confidence intervals) associated with the second and third tertiles of total NNN, relative to the lowest tertile, were 0.82 (0.36-1.88) and 1.02 (0.39-2.89), respectively (p for trend = 0.959), after adjustment for self-reported smoking history, urinary cotinine and PheT. The results of this study reaffirm the previously reported specificity of urinary total NNN and total NNAL as predictors of esophageal and lung cancer risks, respectively, in smokers, and demonstrate remarkable coherence between rat target tissues of these carcinogens and susceptibility to cancer in smokers.</div>
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Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites

Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri